BIOAVAILABILITY ENHANCDEMENT OF POORLY SOLUBLE DRUGS BY SMEDDS: A REVIEW
نویسندگان
چکیده
منابع مشابه
Advanced Delivery of Poorly Water Soluble Drugs by Lipid Based Formulation as Smedds
INTRODUCTION Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Poor aqueous solubility of lipophilic drugs creates problems in formulation as well as in oral administration. Various approaches have been developed to resolve poor aqueous solubility of lipophilic drugs. As oral route for drug administration ...
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Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor water solubility. Drug with poor water solubility cause slow dissolution rates, generally show erratic and incomplete absorption leading to low bioavailability when administered orally. Aqueous solubility of any therapeutically active substance is a key property, as it governs...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2013
ISSN: 2250-1177
DOI: 10.22270/jddt.v3i1.360